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I'm-Yunity® is Based on Sound Research

I'm-Yunity® is a well-researched mushroom health supplement made from the mycelium extract of Yunzhi mushroom (Coriolus Versicolor). Over the last 20 years, our company group has supported studies including clinical trials to identify the active ingredient groups of polysaccharopeptide (PSP) and demonstrate its immune health benefits in the body. Following are a few key findings.To receive more information about PSP research, please email us at

Strong Immunity as Strong Protection

Phase I (21 cases, 1 hospital), Phase II (485 cases, 8 hospitals) and Phase III (650 cases, 14 hospitals) randomized controlled clinical trials showed that our Yunzhi polysaccharopeptide (PSP) supports normal immune function and benefits general well being. These results were reflected in the increase in the activity of natural killer cells[2], increase in the production of interleukin-2[1][2] and increase in the ratio of helper T cells (CD4+) to cytotoxic T cells (CD8+)[1][2] in comparison with the control group.

The above are all immune cells and proteins responsible for guarding against and killing any foreign bodies and abnormal cells in the body. Their increase suggests our Yunzhi polysaccharopeptide (PSP) possess immune supporting benefits and potentially can enhance our immune surveillance.

Maintaining White Blood Cell Levels

Another clinical study carried out by clinical oncologists successfully showed Yunzhi polysaccharopeptide (PSP) was able to maintain white blood cell counts in comparison with a control group.[5] Additionally recently published phase II (34 cases)[7] double-blind, placebo-controlled and randomized clinical trial reported that study subjects taking polysaccharopeptide for four weeks (PSP) had significant improvement in their white blood cell and neutrophil counts, serum Immunoglobin G and Immunoglobin M (two types of antibodies in the serum of blood) (p < 0.05) compared with their pretreatment values.[6]

Increased Immune Proteins

Other experimental studies suggest our Yunzhi polysaccharopeptide (PSP) can induce the increase of cytokines (immune proteins) such as an increase in α and γ-interferon production[7] and an increase of helper T cells (CD4+) under certain experimental conditions[8]. Moreover, Yunzhi polysaccharopeptide (PSP) was shown to activate macrophages, which secrete tumour necrosis factors and other reactive intermediates to mediate immunomodulatory effects[9]. An animal study also suggested Yunzhi polysaccharopeptide (PSP) may counteract the depressive effect of certain drugs on white blood cell counts and interleukin-2 production.[10]

Looking at Drug-Herb Interactions

The most recent clinical study conducted in the US investigated the ability of I'm-Yunity® to inhibit or induce the drug metabolism of CYP3A4 in healthy adult human subjects by using an erythromycin breath test (EBT). A 14-day course of I'm-Yunity® was not associated with any clinically significant CYP3A4 inhibition or induction. This suggests that the administration of I'm-Yunity® with other medications and dietary supplements which are primarily metabolized by CYP3A4, a subtype of the P450 enzyme pathway, is not expected to be associated with significant herb-drug interactions.[11]


  1. Xu. G.M. Phase I clinical test report of PSP capsules. In Proceedings of PSP Intematicnal Symposium (Edited by Yang. Q.Y. and Kowk C.Y.), 179-182 (1993).
  2. Liu, J.X. et al. Phase II clinical trial for PSP capsules. In Proceedings of PSP International Symposium (Edited by Yang. Q.Y. and Kowk C.Y.), 183-208 (1993).
  3. Liu, J.X. Phase III clinil trial for Yun Zhi polysaccharopeptide (PSP) capsules. In Advanced Research in PSP 1999(Edited by Yang. Q.Y.), 295-303 (1999)
  4. Xu. G.M. The effect of PSP on improving immunity for gastric cancer patients. In Proceedings of PSP International Symposium (Edited by Yang. Q.Y. and Kowk C.Y.), 263-264 (1993).
  5. Shui. W.C.T. et al. A clinical study of PSP on peripheral blood counts during chemotherapy. Phytother. Res. 6, 217-218 (1992).
  6. Tsang. K.W. et al. Coriolus versicolor polysaccharide peptide slows progression of advanced non-small cell lung cancer. Resp. Med. 97, 618-624 (2003).
  7. Yang, J.C. The stimulative and inductive effects of Coriolus versicolor polysaccharidepeptide (PSP) on interferon. In Advanced Research in PSP 1999 (Edited by Yang, Q.Y.). 164-167 (1999).
  8. Li, X.Y. Advances in lmmunomodulating studies of PSP. In Advanced Research in PSP 1999 (Edited by Yang, Q.Y.), 39-46 (1999).
  9. Liu, W.K. et al. Evidence that Coriolus versicolor polysaccharide acts on tumor cells through an immunomodulatory effect on macrophages. In Advanced Research in PSP 1999(Edited by Yang, Q.Y.), 187-191 (1999).
  10. Qian, Z.M. et al. Polysaccharide peptide (PSP) restores immunosuppression induced by cyclophosphamide in rats. Am. J Chin. Med. 25, 27-35 (1997).
  11. Guglielmo, B.J. et al. In vivo effect of I'm-Yunity® on Hepatic cytochrome P450 3A4. J. Herb. Pharmacother.7(1), in press.
  12. Ng TB. A review of research on the protein-bound polysaccharide (polysaccharopeptide. PSP) from the mushroom Coriolus versicolor (Basidiomycetes: Polyporaceae). Gen Pharmacol., 30(1), pp. 1-4. (1998)
  13. Nicandro JP, Tsourounis C, Frassetto L and Guglielmo BJ. In vivo effect of I'm-Yunity on hepatic cytochrome P450 3A4, J Herb Pharmacother, 7(1), pp. 39-56. (2007)