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2012 Clinical (Dogs)
܀ Brown, Dorothy Cimino; Reetz, Jennifer. Single agent polysaccharopeptide delays metastases and improves survival in naturally occurring hemangiosarcoma. Evidence-based complementary and alternative medicine. eCAM 2012: 384301, (2012).
2008 In vitro
܀ Wan JM, Sit WH, Louie JC. Polysaccharopeptide enhances the anticancer activity of doxorubicin and etoposide on human breast cancer cells ZR-75-30. Int J Oncol. 32(3):689-699 (2008).
܀ Lee CL, Sit WH, Jiang PP, So IW, Wan JM. Polysaccharopeptide mimics ciclosporin-mediated Th1/Th2 cytokine balance for suppression of activated human T cell proliferation by MAPKp38 and STAT5 pathways. J Pharm Pharmacol. 60(11): 1491-9 (2008).
2007 Clinical (Human)
܀ Guglielmo, B.J. et al. In vivo effect of I'm-Yunity® on Hepatic cytochrome P450 3A4. J. Herb. Pharmacother. 7(1), 39-56 (2007).
In vitro
܀ Lee CL, Jiang PP, Sit WH, Wan JM. Proteome of human T lymphocytes with treatment of cyclosporine and polysaccharopeptide: analysis of significant proteins that manipulate T cells proliferation and immunosuppression. Int Immunopharmacol. 7(10): 1311-24 (2007).
2006 In vitro & animal
܀ Chan, S.L. et al. Effects of polysaccharide peptide (PSP) from Coriolus versicolor on the pharmacokinetics of cyclophosphamide in the rat and cytotoxicity in HepG2 cells. Food Chem. Toxicol. 44, 689-694 (2006).
In vitro
܀ Wu, J.M. et al. Induction of cell cycle changes and modulation of apoptogenic/anti-apoptotic and extracellular signaling regulatory protein expression by water extracts of I'm-Yunity® (PSP). BMC Complement. Altern. Med. 6, 30 (2006)
܀ Hsieh TC and Wu JM. Differential control of growth, cell cycle progression, and gene expression in human estrogen receptor positive MCF-7 breast cancer cells by extracts derived from polysaccharopeptide I'm-Yunity® and Danshen and their combination. Intern J Oncol. 29, 1215-1222 (2006).
2005 Clinical (Human)
܀ Wong, C.K., et al. Immunomodulatory activities of Yunzhi and Danshen in post-treatment breast cancer patients. Am. J. Chin. Med. 33, 381-395 (2005).
In vitro
܀ Zeng, F. et al. Molecular characterization of Coriolus versicolor PSP-induced apoptosis in human promyelotic leukemic HL-60 using cDNA microarray. Int. J. Oncol. 27, 513-523 (2005).
܀ Hui, K.P. et al. Induction of S phase cell arrest and caspase activation by polysaccharide peptide isolated from Coriolus versicolor enhanced the cell cycle dependent activity and apoptotic cell death of doxorubicin and etoposide, but not cytarabine in HL-60 cells. Oncol. Rep. 14, 145-155 (2005).
܀ Yang X. et al. The cell death process of the anticancer agent polysaccharide-peptide (PSP) in human promyelocytic leukemic HL-60 cells. Oncol. Rep. 13, 1201-1210 (2005).
2003 Clinical (Human)
܀ Tsang, K.W. et al. Coriolus versicolor polysaccharide peptide slows progression of advanced non-small cell lung cancer. Resp. Med. 97, 618-624 (2003).
2002 In vitro
܀ Hsieh, T.C. Wu, J.M. et al. Effects of extracts of Coriolus versicolor (I'm Yunity®) on cell-cycle progression and expression of Interleukins-1β, -6, and -8 in promyelocytic HL-60 leukemic cells and mitogenically stimulated and nonstimulated human lymphocytes. J. Altern. Complem. Med. 8, 591-602 (2002).
2001 In vitro
܀ Hsieh, T.C. Wu, J.M. et al. Cell growth and gene modulatory activities of Yunzhi (Winsor Wunxi) from mushroom Trametes versicolor in androgen-dependent and androgen-insensitive human prostate cancer cells. Int. J. Oncol. 18, 81-88 (2001).
܀ Mao, X.W. et al. Evaluation of polysaccharopeptide effects against C6 glioma in combination with radiation. Oncology. 61, 243-246 (2001).
2000 Review
܀ Kidd, P.M. The use of mushroom glucans and proteoglycans in cancer treatment. Altern. Med. Rev. 5, 4-27 (2000).